Yaw Sing Tan: search on Z-Library

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1

Stapled peptides as a new technology to investigate protein-protein interactions in human platelets

iegre, jessica, Ahmed, Niaz S, Gaynord, Josephine S, Wu, Yuteng, Herlihy, Kara M, Tan, Yaw Sing, Lopes-Pires, Maria E, Jha, Rupam, Lau, Yu Heng, Sore, Hannah, Verma, Chandra, O'Donovan, Daniel H, Pugh

Journal:

Chemical Science

Year:

2018

Language:

english

File:

PDF, 1.40 MB

english, 2018

2

Functional characterization of p53 pathway components in the ancient metazoan Trichoplax adhaerens

Siau, Jia Wei, Coffill, Cynthia R., Zhang, Weiyun Villien, Tan, Yaw Sing, Hundt, Juliane, Lane, David, Verma, Chandra, Ghadessy, Farid

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 1.40 MB

english, 2016

3

Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase

Xu, Wenshu, Lau, Yu Heng, Fischer, Gerhard, Tan, Yaw Sing, Chattopadhyay, Anasuya, de la Roche, Marc, Hyvönen, Marko, Verma, Chandra, Spring, David R., Itzhaki, Laura S.

Journal:

Journal of the American Chemical Society

Year:

2017

Language:

english

File:

PDF, 15.71 MB

english, 2017

4

Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides

Lau, Yu Heng, Wu, Yuteng, Rossmann, Maxim, Tan, Ban Xiong, de Andrade, Peterson, Tan, Yaw Sing, Verma, Chandra, McKenzie, Grahame J., Venkitaraman, Ashok R., Hyvönen, Marko, Spring, David R.

Journal:

Angewandte Chemie International Edition

Year:

2015

Language:

english

File:

PDF, 2.00 MB

english, 2015

5

Macrocyclic α Helical Peptide Therapeutic Modality: A Perspective of Learnings and Challenges

Sawyer, Tomi K., Partridge, Anthony, Kaan, Hung Yi Kristal, Juang, Yu-Chi, Lim, Shuhui, Johannes, Charles, Yuen, Tsz Ying, Verma, Chandra, Kannan, Srinivasaraghavan, Aronica, Pietro, Sing, Tan Yaw, Sh

Journal:

Bioorganic & Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.47 MB

english, 2018

6

The Application of Ligand-Mapping Molecular Dynamics Simulations to the Rational Design of Peptidic Modulators of Protein–Protein Interactions

Tan, Yaw Sing, Spring, David R., Abell, Chris, Verma, Chandra S.

Journal:

Journal of Chemical Theory and Computation

Year:

2015

Language:

english

File:

PDF, 7.00 MB

english, 2015

7

Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides

Lau, Yu Heng, Wu, Yuteng, Rossmann, Maxim, Tan, Ban Xiong, de Andrade, Peterson, Tan, Yaw Sing, Verma, Chandra, McKenzie, Grahame J., Venkitaraman, Ashok R., Hyvönen, Marko, Spring, David R.

Journal:

Angewandte Chemie

Year:

2015

Language:

english

File:

PDF, 1.99 MB

english, 2015

8

A comparison of the dynamics of pantothenate synthetase from M. tuberculosis and E. coli: Computational studies

Yaw Sing Tan, Gloria Fuentes, Chandra Verma

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2011

Language:

english

File:

PDF, 4.67 MB

english, 2011

9

Ultra-High Signal Detection of Human Embryonic Stem Cells Driven by Two-Dimensional Materials

Chan, Sophia S. Y., Tan, Yaw Sing, Wu, Kan-Xing, Cheung, Christine, Loke, Desmond K.

Journal:

ACS Applied Bio Materials

Year:

2018

Language:

english

File:

PDF, 5.73 MB

english, 2018

10

Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles

Yuen, Tsz Ying, Brown, Christopher J., Xue, Yuezhen, Tan, Yaw Sing, Ferrer Gago, Fernando J., Lee, Xue Er, Neo, Jin Yong, Thean, Dawn, Kaan, Hung Yi Kristal, Partridge, Anthony W., Verma, Chandra S.,

Journal:

Chemical Science

Year:

2019

File:

PDF, 1.16 MB

2019

11

A strategy for the diversity-oriented synthesis of macrocyclic scaffolds using multidimensional coupling

Beckmann, Henning S. G., Nie, Feilin, Hagerman, Caroline E., Johansson, Henrik, Tan, Yaw Sing, Wilcke, David, Spring, David R.

Journal:

Nature Chemistry

Year:

2013

Language:

english

File:

PDF, 1.53 MB

english, 2013

12

Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer

Wiedmann, Mareike M., Tan, Yaw Sing, Wu, Yuteng, Aibara, Shintaro, Xu, Wenshu, Sore, Hannah F., Verma, Chandra S., Itzhaki, Laura, Stewart, Murray, Brenton, James D., Spring, David R.

Journal:

Angewandte Chemie International Edition

Year:

2017

Language:

english

File:

PDF, 1.96 MB

english, 2017

13

Discovery of an inhibitor of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells

Morkunas, Bernardas, Gal, Balint, Galloway, Warren R J D, Hodgkinson, James T, Ibbeson, Brett M, Sing Tan, Yaw, Welch, Martin, Spring, David R

Journal:

Beilstein Journal of Organic Chemistry

Year:

2016

Language:

english

File:

PDF, 2.50 MB

english, 2016

14

Anatomy of Mdm2 and Mdm4 in evolution

Tan, Ban Xiong, Liew, Hoe Peng, Chua, Joy S., Ghadessy, Farid J., Tan, Yaw Sing, Lane, David P., Coffill, Cynthia R.

Journal:

Journal of Molecular Cell Biology

Year:

2017

Language:

english

File:

PDF, 1.53 MB

english, 2017

15

Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide

Liu, Bee Hui, Jobichen, Chacko, Chia, C. S. Brian, Chan, Tim Hon Man, Tang, Jing Ping, Chung, Theodora X. Y., Li, Jia, Poulsen, Anders, Hung, Alvin W., Koh-Stenta, Xiaoying, Tan, Yaw Sing, Verma, Chan

Journal:

Proceedings of the National Academy of Sciences

Year:

2018

Language:

english

File:

PDF, 2.03 MB

english, 2018

16

Using Ligand-Mapping Simulations to Design a Ligand Selectively Targeting a Cryptic Surface Pocket of Polo-Like Kinase 1

Yaw Sing Tan, Dr. Paweł Śledź, Dr. Steffen Lang, Christopher J. Stubbs, Dr. David R. Spring, Prof. Chris Abell, Dr. Robert B. Best

Journal:

Angewandte Chemie International Edition

Year:

2012

Language:

english

File:

PDF, 1.23 MB

english, 2012

17

Synthesis of Chiral Alkenyl Cyclopropane Amino Acids for Incorporation into Stapled Peptides

Yuen, Tsz Ying, Brown, Christopher J., Tan, Yaw Sing, Johannes, Charles William

Journal:

Journal of Organic Chemistry

Year:

2019

File:

PDF, 482 KB

2019

18

Straightforward incorporation of multiple ligand types into molecular dynamics simulations for efficient binding site detection and characterization

Tan, Yaw Sing, Verma, Chandra S.

Journal:

Journal of Chemical Theory and Computation

Year:

2020

File:

PDF, 1.41 MB

2020

19

Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles

Yuen, Tsz Ying, Brown, Christopher J., Xue, Yuezhen, Tan, Yaw Sing, Ferrer Gago, Fernando J., Lee, Xue Er, Neo, Jin Yong, Thean, Dawn, Kaan, Hung Yi Kristal, Partridge, Anthony W., Verma, Chandra S.,

Journal:

Chemical Science

Year:

2019

Language:

english

File:

PDF, 1.16 MB

english, 2019

20

Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell

Chattopadhyay, Anasuya, O’Connor, Cornelius J., Zhang, Fengzhi, Galvagnion, Celine, Galloway, Warren R. J. D., Tan, Yaw Sing, Stokes, Jamie E., Rahman, Taufiq, Verma, Chandra, Spring, David R., Itzhak

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 1.49 MB

english, 2016

21

Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer

Wiedmann, Mareike M., Tan, Yaw Sing, Wu, Yuteng, Aibara, Shintaro, Xu, Wenshu, Sore, Hannah F., Verma, Chandra S., Itzhaki, Laura, Stewart, Murray, Brenton, James D., Spring, David R.

Journal:

Angewandte Chemie

Year:

2017

Language:

english

File:

PDF, 3.12 MB

english, 2017

22

Using Ligand-Mapping Simulations to Design a Ligand Selectively Targeting a Cryptic Surface Pocket of Polo-Like Kinase 1

Yaw Sing Tan, Dr. Paweł Śledź, Dr. Steffen Lang, Christopher J. Stubbs, Dr. David R. Spring, Prof. Chris Abell, Dr. Robert B. Best

Journal:

Angewandte Chemie

Year:

2012

Language:

english

File:

PDF, 1.22 MB

english, 2012

23

Diversity-oriented synthesis as a tool for identifying new modulators of mitosis

Ibbeson, Brett M., Laraia, Luca, Alza, Esther, O' Connor, Cornelius J., Tan, Yaw Sing, Davies, Huw M.L., McKenzie, Grahame, Venkitaraman, Ashok R., Spring, David R.

Journal:

Nature Communications

Year:

2014

Language:

english

File:

PDF, 786 KB

english, 2014

24

Fatigue Analysis of Light Aircraft Landing Gear

Chen, Pu Woei, Sheen, Quen Yaw, Tan, Harn Wen, Sun, Tai Sing

Journal:

Advanced Materials Research

Year:

2012

Language:

english

File:

PDF, 381 KB

english, 2012

25

The p53–Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humans

Coffill, Cynthia R., Lee, Alison P., Siau, Jia Wei, Chee, Sharon M., Joseph, Thomas L., Tan, Yaw Sing, Madhumalar, Arumugam, Tay, Boon-Hui, Brenner, Sydney, Verma, Chandra S., Ghadessy, Farid J., Venk

Journal:

Genes & Development

Year:

2016

Language:

english

File:

PDF, 1.33 MB

english, 2016

26

Stapled peptide design: principles and roles of computation

Tan, Yaw Sing, Lane, David P., Verma, Chandra S.

Journal:

Drug Discovery Today

Year:

2016

Language:

english

File:

PDF, 2.05 MB

english, 2016

27

Necrotizing Fasciitis After Laparoscopic Colonic Surgery

Tan, Lincoln Guan Lim, See, Ju Yaw, Wong, Kutt Sing

Journal:

Surgical Laparoscopy Endoscopy & Percutaneous Techniques

Year:

2007

Language:

english

File:

PDF, 75 KB

english, 2007

28

A diversity-oriented synthesis strategy enabling the combinatorial-type variation of macrocyclic peptidomimetic scaffolds

Isidro-Llobet, Albert, Hadje Georgiou, Kathy, Galloway, Warren R. J. D., Giacomini, Elisa, Hansen, Mette R., Méndez-Abt, Gabriela, Tan, Yaw Sing, Carro, Laura, Sore, Hannah F., Spring, David R.

Journal:

Organic & Biomolecular Chemistry

Year:

2015

Language:

english

File:

PDF, 3.98 MB

english, 2015

29

The Use of Chlorobenzene as a Probe Molecule in Molecular Dynamics Simulations

Tan, Yaw Sing, Spring, David R., Abell, Chris, Verma, Chandra

Journal:

Journal of Chemical Information and Modeling

Year:

2014

Language:

english

File:

PDF, 4.06 MB

english, 2014

30

Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design

Tan, Yaw Sing, Reeks, Judith, Brown, Christopher J., Thean, Dawn, Ferrer Gago, Fernando Jose, Yuen, Tsz Ying, Goh, Eunice Tze Leng, Lee, Xue Er Cheryl, Jennings, Claire E., Joseph, Thomas L., Lakshmin

Journal:

The Journal of Physical Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 3.87 MB

english, 2016

31

An Intramolecular Tryptophan-Condensation Approach for Peptide Stapling

Hui, Yen Li Eunice, Rout, Bhimsen, Tan, Yaw Sing, Verma, Chandra, Chan, Kok-Ping, Johannes, Charles W.

Journal:

Organic & Biomolecular Chemistry

Year:

2017

Language:

english

File:

PDF, 915 KB

english, 2017

32

Kinetic and thermodynamic effects of phosphorylation on p53 binding to MDM2

Yadahalli, Shilpa, Neira, José L., Johnson, Christopher M., Tan, Yaw Sing, Rowling, Pamela J. E., Chattopadhyay, Anasuya, Verma, Chandra S., Itzhaki, Laura S.

Journal:

Scientific Reports

Year:

2019

Language:

english

File:

PDF, 2.12 MB

english, 2019

33

Synthesis and biological profiling of tellimagrandin I and analogues reveals that the medium ring can significantly modulate biological activity

Zheng, Shaojun, Laraia, Luca, O' Connor, Cornelius J., Sorrell, David, Tan, Yaw Sing, Xu, Zhaochao, Venkitaraman, Ashok R., Wu, Wenjun, Spring, David R.

Journal:

Organic & Biomolecular Chemistry

Year:

2012

Language:

english

File:

PDF, 666 KB

english, 2012

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